Application of 445-02-3,Some common heterocyclic compound, 445-02-3, name is 4-Bromo-2-(trifluoromethyl)aniline, molecular formula is C7H5BrF3N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Isopentyl nitrite (0. 67ML) was added dropwise to a solution of 4-bromo-2- (trifluoromethyl) aniline (1.2g) and dimethyl sulfide (0. 45ML) in acetonitrile (12ML). The reaction was slowly heated to reflux and then refluxed until gas evolution ceased. The volatiles were evaporated, the residue absorbed onto silica and the product eluted off with isohexane. YIELD 0. 8G. 1H NMR DMSO-d6: 8 7.59 (dd, 2H), 7.23 (d, 1H), 2.51 (s, 3H)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Bromo-2-(trifluoromethyl)aniline, its application will become more common.
Reference:
Patent; ASTRAZENECA AB; WO2004/89885; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary