Reference of 201138-91-2,Some common heterocyclic compound, 201138-91-2, name is 4,6-Dibromodibenzo[b,d]furan, molecular formula is C12H6Br2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under an argon atmosphere, to a 1,000 ml Erlenmeyer flask, 4,6-dibromodibenzofuran (16.3 g, 50 mmol), phenylboronic acid (6.71 g, 55 mmol), K2CO3 (20.7 g, 150 mmol), Pd(PPh3)4(2.89 g, 2.5 mmol), 500 ml of a mixture solution of toluene/EtOH/H2O (4/2/1) were added in order, followed by heating and refluxing at a temperature of about 80 C. for about 5 hours. Then, the reaction mixture was cooled to room temperature, and toluene was added thereto. An aqueous layer was removed, and an organic layer was washed with a saline solution and dried with MgSO4. MgSO4 was filtered and separated, and an organic layer was concentrated. The crude product thus obtained was separated by silica gel column chromatography (using a mixture solvent of hexane/toluene) and recrystallized to obtain Intermediate A as a white solid (12.1 g, yield 75%). The structure of the product was identified using FAB-MS (m/z=323).
The synthetic route of 201138-91-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Samsung Display Co., Ltd.; UNO, Takuya; (209 pag.)US2019/165285; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary