Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7051-34-5, name is (Bromomethyl)cyclopropane, A new synthetic method of this compound is introduced below., Safety of (Bromomethyl)cyclopropane
L-Cysteine (100 g, 0.825 mol) was suspended in ethanol (850 mL). A solution of sodium hydroxide (1.65 mol) in ethanol (650 mL) was added during 40 min at 20-25 C. To the solution was added bromomethylcyclopropane (0.907 mol) at 25-30 C. The reaction mixture was stirred at ambient temperature overnight, the neutralized with 2N HCl (300 mL). The suspension was concentrated under vacuum to 400 mL, then water (750 mL) was added, and pH was adjusted to 6.5 with 2N HCl. The mixture was stirred for 2 h at 0-5 C., the precipitate was filtered, washed with water and dried under vacuum to give (R)-2-amino-3-cyclopropyl-methylsulfanylpropionic acid as a white crystalline solid (128.2 g; yield=88.6 %). C7H13NO2S; MW=175.3; Tmelt=2090 C; NMR (DMSO, ppm): 0.20 (m, 2H), 0.50 (m, 2H), 0.94 (m, 1H), 2.50 (m, 2H), 2.78 (dd, J=14.5 and 8.5 Hz, 1 H), 3.08 (dd, J=14.5 and 4 Hz, 1 H) and 7.64 (ls, 1H (mobile)); SM (EI; m/z): 130 (M+-COOH), 89, 74.
The synthetic route of 7051-34-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AXYS PHARMACEUTICALS, INC.; AVENTIS PHARMACEUTICALS, INC.; US2004/19218; (2004); A1;,
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