Reference of 13633-25-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13633-25-5, name is 1-Bromo-4-phenylbutane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A mixture of 8d hydrochloride (0.15 g, 0.53 mmol), N-ethyldiisopropylamine(0.34 g, 2.7 mmol) and sodium hydride (0.07 g,1.8 mmol) in DMF (5 mL) was stirred for 0.5 h at rt. To the mixturewas added 4-phenylbutylbromide (0.50 g, 2.35 mmol) in an icebath,and the mixture was stirred for 2 h at 120 C. The mixturewas partitioned between ethyl acetate and water, and the aqueouslayer was extracted with ethyl acetate. The combined organic layerwas washed with brine, dried (Na2SO4) and concentrated in vacuo.The residue was purified by column chromatography on basic silicagel (n-hexane/EtOAc = 15/1-10/1) to produce pale brown oils, to asolution of which in ether (5 mL) was added 4 N HCl/EtOAc(0.15 mL, 0.6 mmol) dropwise in an ice-bath, and the precipitatewas filtered off to obtain 3g (0.15 g, 66%) as pale brown crystals.1H NMR (DMSO-d6) d 1.40-2.73 (14H, m), 2.80-3.40 (6H, m),3.87 (3H, s), 6.99-7.03 (2H, m), 7.16-7.32 (5H, m), 7.97 (1H, d,J = 8.4 Hz), 9.45 (1H, brs); Anal. Calcd for C25H32NO2ClHCl0.5H2O:C, 70.99; H, 7.86; N, 3.31. Found: C, 71.75; H, 8.26; N, 3.32; LC/MS(ESI) m/z 378 (M+H)+.
The synthetic route of 1-Bromo-4-phenylbutane has been constantly updated, and we look forward to future research findings.
Reference:
Article; Imaeda, Toshihiro; Ono, Koji; Nakai, Kazuo; Hori, Yasunobu; Matsukawa, Jun; Takagi, Terufumi; Fujioka, Yasushi; Tarui, Naoki; Kondo, Mitsuyo; Imanishi, Akio; Inatomi, Nobuhiro; Kajino, Masahiro; Itoh, Fumio; Nishida, Haruyuki; Bioorganic and Medicinal Chemistry; vol. 25; 14; (2017); p. 3719 – 3735;,
Bromide – Wikipedia,
bromide – Wiktionary