Adding a certain compound to certain chemical reactions, such as: 4885-18-1, name is 1-(3-Bromophenyl)-N,N-dimethylmethanamine, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4885-18-1, Quality Control of 1-(3-Bromophenyl)-N,N-dimethylmethanamine
Example A135. (l R*.2S*)-2-(3-(3-((dimethylamino)methvnstyrvn-lH-indazol-6-yl)-5′- methoxyspiro[cyclopropane-l,3′-indolinl-2′-one 2,2,2-trifluoroacetate To a mixture of crude (l R*,2S*)-5′-methoxy-2-(3-vinyl-lH-indazol-6- yl)spiro[cyclopropane-l ,3′-indolin]-2′-one (100 mg, 0.2 mmol), l-(3-bromophenyl)-N,N- dimethylmethanamine (43 mg, 0.2 mmol), Pd(OAc)2 (2.2 mg, 0.01 mmol) and P(o-tol)3 (6.7 mg, 0.022 mmol) in DMF (2 mL) was added 1Pr2NEt (0.07 mL, 0.4 mmol). The resulting mixture was purged with argon, then microwaved 30 min at 125 0C. It was passed through a micro filter then purified by prep-HPLC to give the title compound as a light yellow solid. NMR indicated 7% branched isomer (43 mg, 37%). Spectral data was identical to that in obtained in Example A 134.
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Reference:
Patent; UNIVERSITY HEALTH NETWORK; SAMPSON, Peter Brent; Ll, Sze-Wan; LIU, Yong; PAULS, Heinz W.; EDWARDS, Louise G.; FORREST, Bryan T.; FEHER, Miklos; PATEL, Narendra Kumar B.; PAN, Guohua; WO2010/115279; (2010); A1;,
Bromide – Wikipedia,
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