Reference of 73918-56-6,Some common heterocyclic compound, 73918-56-6, name is 2-(4-Bromophenyl)ethanamine, molecular formula is C8H10BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Into a 1-L 3 -necked round-bottom flask was added 2-(4-bromophenyl)ethan-l -amine (80.0 g, 400 mrnol), anhydrous DCM (800 mL), and TEA (48.7 g, 67, 1 mL, 481mmol). The resulting mixture was cooled to 0 C’C and then a solution of benzyl chioroformate (68.3 g, 56.9 mL, 400 mrnol) in anhydrous DCM (20 mL) was added dropwise. The resulting solution was stirred for 2 h at 0 C and then concentrated in vacuo. The cmde product was purified via silica gel chromatography and eluted with ethyl acetate/petroleum ether (1 :3) to afford benzyl N-[2-(4- bromophenyi)ethylJcarbamate as a white solid (100 g, 75%). LCMS (ESI, m/z): 334 [M+H]+
The synthetic route of 73918-56-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; FORMA THERAPEUTICS, INC.; GUERIN, David Joseph; BAIR, Kenneth W.; CARAVELLA, Justin A.; IOANNIDIS, Stephanos; LANCIA, JR., David R.; LI, Hongbin; MISCHKE, Steven; NG, Pui Yee; RICHARD, David; SCHILLER, Shawn E.R.; SHELEKHIN, Tatiana; WANG, Zhongguo; (113 pag.)WO2017/139779; (2017); A1;,
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