Reference of 50548-45-3, These common heterocyclic compound, 50548-45-3, name is 1-Bromodibenzo[b,d]furan, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(4) In a 1L reaction flask, add intermediate c (51.65 g, 100 mmol), 9,9-dimethyl-9H-fluoren-2-amine (20.93 g, 100 mmol), and tris (dibenzylideneacetone). ) Dipalladium (2.75g, 3mmol), tri-tert-butylphosphine (1.21g, 6mmol), sodium tert-butoxide (19.22g, 200mmol), 500ml of toluene, under a nitrogen atmosphere, heated to 110 C for 12h, the liquid The phase monitoring reaction was completed, the temperature was reduced, 1-bromodibenzofuran (24.71 g, 100 mmol) was added, and the temperature was raised to 110 C to continue the reaction for 8 hours. After drying, 51.09 g of intermediate e can be obtained with a yield of 63%
The synthetic route of 50548-45-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Wuhan Shang Sai Optoelectric Technology Co., Ltd.; Mu Guangyuan; Zhuang Shaoqing; Ren Chunting; (31 pag.)CN110372570; (2019); A;,
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