Related Products of 114078-88-5,Some common heterocyclic compound, 114078-88-5, name is 5-Bromo-1,2,3-triazine, molecular formula is C3H2BrN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Using the most conditional verification experiment, the reaction steps are: in a 10mL dry sealed reaction tube, add 5-bromo-1,2,3-triazine 1a (15.9mg, 0.10mmol), DBN (37.3 mg, 0.30 mmol) and diethyl cyanomethyl phosphate 1b (35.4 mg, 0.20 mmol). After nitrogen substitution three times, the solvent 1,4-dioxane (1.0 mL) was added, and the sealed reaction tube was placed at 70 C to react. The reaction was monitored by TLC. After the reaction was completed, it was extracted with dichloromethane (3 * 10mL). The organic phase was dried over anhydrous sodium sulfate and concentrated in vacuo. After column chromatography, the target product 1c (24.6mg) was obtained. 80%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Bromo-1,2,3-triazine, its application will become more common.
Reference:
Patent; Chongqing University; Li Baosheng; Luo Han; Zhang Yuan; An Jiaoyu; Xu Mingchuan; Lu Qixing; Tang Zongyuan; Li Shanshan; (16 pag.)CN111004284; (2020); A;,
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