These common heterocyclic compound, 7051-34-5, name is (Bromomethyl)cyclopropane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 7051-34-5
[>^CO2Et[1,3] Dithiane-2-carboxylic acid ethyl ester (1.29 g, 6.71 mmol) and bromomethyl-cyclopropane (0.99 g, 7.38 mmol) dissolved in dry DMF (1 mL), was added slowly to a stirred suspension of NaH (60 % in mineral oil, 268 mg, 6.71 mmol) in dry toluene (2 mL). The mixture was stirred at room temperature overnight and LC-MS showed completion of the reaction. The reaction was quenched with H2O, diluted with EtOAc. The organic layers were washed with H2O and dried with MgSO^ The solution was filtered and concentrated in vacuo to give desired product, 2-cyclopropylmethyl-[l,3]dithiane-2-carboxyIic acid ethyl ester, as yellow oil (1.49 g, 91%). LC-MS (ESI+): m/e = 247.0 [M+l]+ (exact ms: 246.07).
The synthetic route of (Bromomethyl)cyclopropane has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ANADYS PHARMACEUTICALS, INC.; WO2008/82725; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary