Synthetic Route of 58534-95-5,Some common heterocyclic compound, 58534-95-5, name is 3-Bromo-2-fluoroaniline, molecular formula is C6H5BrFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The mixture of 12 (30 g), 13 (60 g), K2CO3 (91 g) and Pd(dppf)2Cl2 (19.25 g) in solvent (dioxane 400 mL, H2O 100 mL) was purged with argon in a pressure vessel for 5 min and stirred for 15 h at 100 C. The solvent was removed under reduced pressure and the remaining residue was purified by flash column chromatography. The purified material was then dissolved in MeOH and treated with HCl/MeOH. The solvent was removed and the remaining solid was washed with IPA-heptane (1/1) to afford 14.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Bromo-2-fluoroaniline, its application will become more common.
Reference:
Patent; Achillion Pharmaceuticals, Inc.; Gadhachanda, Venkat Rao; Pais, Godwin; Hashimoto, Akihiro; Wang, Qiuping; Chen, Dawei; Wang, Xiangzhu; Agarwal, Atul; Deshpande, Milind; Phadke, Avinash S.; Wiles, Jason Allan; US2015/239920; (2015); A1;,
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