In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 955959-84-9 as follows. COA of Formula: C18H11BrO
In a 250mL flask, 4-(4′-bromophenyl)dibenzo[b,d]furan (10g) and tetrahydrofuran (90mL) were mixed and stirred under nitrogen atmosphere and cooled to -78°C. At -78°C, n-butyllithium (18.8ml, 2.5M in n-hexane) was added and stirred for 2 hours. After 2 hours, trimethyl borate (16g) was added and the reaction was equilibrated to room temperature overnight. The reaction was monitored by thin layer chromatography. Upon completion of the reaction, 2N hydrochloric acid solution (60mL) was added and stirred for 1 hour. It was quenched with water (50mL) and extracted with ethyl acetate (70mL). The organic layer was extracted with water (3x50mL) and dried over anhydrous sodium sulfate. Following this, the ethyl acetate layer was evaporated to dryness under vacuum rotavap to get 4-(dibenzofuran-4-yl)phenylboronic acid (5g).
According to the analysis of related databases, 955959-84-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; e-Ray Optoelectronics Technology Co., Ltd.; Ban, Ruman; Huang, Helong; Yao, Zhengcong; Xie, Bowei; Chen, Huixu; (34 pag.)CN105585555; (2016); A;,
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