Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1647-26-3, name is 1-Bromo-2-cyclohexylethane, A new synthetic method of this compound is introduced below., SDS of cas: 1647-26-3
solution of tert-butyl {6-[({[(Z)-(4-methyl-5-oxo-4,5-dihydro-1 ,2,4-oxadiazol-3- yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}carbamate (100 mg, 0.235 mmol, 1 eq.) in A/,/V-dimethylformamide (2 ml) was treated with sodium hydride (10 mg, 0.259 mmol, 1.1 eq.) and stirred at room temperature for 30 minutes. (2-Bromoethyl)cyclohexane (67 mg, 0.353 mmol, 1.5 eq.) was then added and stirring was allowed overnight. The reaction was quenched by addition of water and extracted with EtOAc (3 x 20 ml). The organics were combined, washed with aq. sat. NaCI. dried over gSO and concentrated to afford tert-butyl (2- cyclohexylethyl ){6-[({[(Z)-(4-methyl-5-oxo-4 , 5-d i hyd ro- 1 ,2 ,4-oxad iazol-3- yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}carbamate (108 mg, 86% yield) which was used in the next step without further purification.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; BAYER INTELLECTUAL PROPERTY GmbH; BRAUN, Christoph; SAWADA, Haruko; LACHAISE, Helene; BRUNET, Stephane; RINOLFI, Philippe; DUBOST, Christophe; COQUERON, Pierre-Yves; MAECHLING, Simon; REBSTOCK, Anne-Sophie; WACHENDORFF-NEUMANN, Ulrike; WO2013/37717; (2013); A1;,
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