In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 627871-16-3, name is 5-Bromo-4-fluoro-2-methylaniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 627871-16-3
5-bromo-4-fluoro-2-methylaniline (1) (20g, 98 mmol) was dissolved in anhydrous l-methyl-2-pyrrolidinone (10 mL), and copper (I) cyanide (17.6g, 196 mmol) was added. The reaction was heated to about 180 C for 3 about 3 hours, cooled to room temperature, and water (300 mL) and concentrated ammonium hydroxide (300 mL) added. The mixture was stirred for about 30 minutes, then extracted with ethyl acetate (3 x 200 mL). The combined extracts were dried over magnesium sulfate, and the solvent was removed under reduced pressure. The oily residue was washed with hexanes (2 x 100 mL), and the solid dissolved in dichloromethane and loaded onto a silica gel column. Eluting with 0 to 25% ethyl acetate in hexanes gradient provided 5-amino-2-fluoro-4- methylbenzonitrile. LC/MS (m/z:151 M+1).
The synthetic route of 627871-16-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GILEAD SCIENCES, INC.; ALLEVA, Jennifer, Lynne; DEMPAH, Kassibla, Elodie; FARAND, Julie; NOTTE, Gregory; (128 pag.)WO2018/169742; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary