Adding a certain compound to certain chemical reactions, such as: 103273-01-4, name is 2-Bromo-4-(tert-butyl)aniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 103273-01-4, SDS of cas: 103273-01-4
200 mL three-necked eggplant flask fully dried (condenser, three-way cock, To a magnetic stirring bar) was added 2-methoxyphenylboronic acid (Wako Pure Chemical Industries, Ltd.) (3.19 g, 10.5 mmol), (0.05 mmol) of 2-bromo-4-tert-butylaniline (2.8 g, 10 mmol), palladium acetate (manufactured by Wako Pure Chemical Industries, Ltd.), 2-dicyclohexylphosphino-2′,6-dimethoxybiphenyl (Manufactured by Sigma-Aldrich Japan Co., Ltd.) (0.041 g, 0.1 mmol) 6.9 g (30 mmol) of potassium phosphate monohydrate (manufactured by Wako Pure Chemical Industries, Ltd.) In addition, suspended in 20 mL of toluene (manufactured by Kanto Chemical Co., Ltd.) The reaction was carried out at 100 C. for 3 hours. To this reaction solution was added 50 mL of water, After extraction with toluene, the organic layer was dried with MgSO 4 (manufactured by Kanto Kagaku Co., Ltd.) The solvent was distilled off under reduced pressure to obtain a crude product. The crude product was purified by silica gel column chromatography (eluent; hexane (Manufactured by KANTO CHEMICAL CO., LTD.) / Ethyl acetate (manufactured by KANTO CHEMICAL CO., LTD.) = 9/1) to obtain 2.40 g (94%, light yellow liquid) of Compound
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-4-(tert-butyl)aniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Mitsui Chemicals Co., Ltd.; Kinoshita, Shinsuke; Kawamura, Kazumori; Ishii, Seiichi; Tanaka, Kenichi; Hanada, shiori; Saito, Yasunori; Hara, Retsu; Mizobuchi, Yusuke; Muroto, Toshihiro; (55 pag.)JP5769443; (2015); B2;,
Bromide – Wikipedia,
bromide – Wiktionary