Adding a certain compound to certain chemical reactions, such as: 58971-11-2, name is 3-Bromophenethylamine, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 58971-11-2, Application In Synthesis of 3-Bromophenethylamine
[00981] Example 62. Preparation of N-(6-(3-fer?-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-l(2H)-yl)-2- methoxyphenyl)-3,4-dihydroisoquinolin-2(lH)-yl)methanesulfonamide (compound IB-LO-2.43).; [00982] Part A. Preparation of N-(3-bromophenethyl)-2,2,2-trifluoroacetamide.; [00983] To a solution of 2-(3-bromophenyl)ethanamine (1Og, 50.0mmol) in dichloromethane (200ml) atO0C were added 2,6-lutidine (6.40ml, 55.0mmol) and then trifluoroacetic anhydride (7.77ml, 55.0mmol) dropwise, and the reaction was stirred at room temperature overnight. Water was added at 00C and the reaction was washed with IM HCl, H2O, and sat NaHCO3. The organic was dried overmgSO4, filtered and concentrated to provide the title compound as a tan solid (14.7g, 99%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Bromophenethylamine, and friends who are interested can also refer to it.
Reference:
Patent; ABBOTT LABORATORIES; WO2009/39134; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary