These common heterocyclic compound, 630-17-1, name is 1-Bromo-2,2-dimethylpropane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 1-Bromo-2,2-dimethylpropane
1-neopentyl-4-(4-nitrophenyl)-1H-imidazole To a solution of 4-(4-nitrophenyl)-1H-imidazole (0.500 g, 2.64 mmol) in N,N-dimethylformamide (10 ml) was added cesium carbonate (1.292 g, 3.96 mmol) followed by 1-bromo-2,2-dimethylpropane (0.366 ml, 2.91 mmol). After heating at 850 overnight, the reaction mixture was cooled to room temperature, diluted with ethyl acetate, washed with water and brine, dried over magnesium sulfate, filtered and concentrated. Normal phase chromatography provided the title compound.
The synthetic route of 1-Bromo-2,2-dimethylpropane has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AbbVie Inc.; Hansen, Todd M.; Longenecker, Kenton; Heyman, Howard R.; Curtin, Michael L.; Clark, Richard F.; Sorensen, Bryan; Ji, Zhiqin; Woller, Kevin; Doherty, George; Frey, Robin; (246 pag.)US2017/65575; (2017); A1;,
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