Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 454-79-5, name is 2-Bromo-5-(trifluoromethyl)aniline, A new synthetic method of this compound is introduced below., Product Details of 454-79-5
In an air atmosphere, 1.0 mmol of 5-chloro-2-hydroxybenzylalcohol was added to a 10 ml flask,1.2 mmol of 5-trifluoromethyl-2-bromoaniline, 0.01 mmol of p-cymene ruthenium dichloride dimer, 0.05 mmol of cuprous iodide, 0.1 mmol of 1,1′-bis (dicyclohexylphosphine) Ferrocene,9.0 mmol of potassium tert-butoxide, and 5 ml of toluene, and then placed on a condenser tube heated to 110 C with an oil bath under magnetic agitation and reacted for 18 hours. The oil bath was removed, 3 ml of water was added to the reaction mixture and the mixture was extracted three times with 5 ml of ethyl acetate. The organic phases were combined and dried over anhydrous magnesium sulfate for 30 minutes. The filtrate was concentrated on a rotary evaporator. The concentrated solid was extracted with methylene chloride Recrystallization gave pure product 19 in 82% yield.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Luoyang Normal College; Xu Chen; Li Hongmei; Wang Zhiqiang; Lou Xinhua; Fu Weijun; (11 pag.)CN105949143; (2016); A;,
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