Adding a certain compound to certain chemical reactions, such as: 21865-50-9, name is 6-Bromo-2,3,4,9-tetrahydro-1H-carbazole, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 21865-50-9, Quality Control of 6-Bromo-2,3,4,9-tetrahydro-1H-carbazole
A sample of 6-Bromo-2,3,4,9-tetrahydro carbazole (0.498g, 2 mmol) was dissolved in 4 ml of dry DMF. To this stirred solution, NaH (60% suspension; 0.24g, 6 mmol) was added portion wise followed by the addition of diethyl sulfate (0.79ml, 6 mmol). The reaction mixture was heated to 80 0C overnight. The TLC of mixture, with 4:6 dichloromethane/hexane, showed complete consumption of starting material and a new spot with higher Rf value. The reaction mixture was added to 60 ml of ice cold H2O, the mixture was extracted with EtOAc and washed with sat. brine solution. The organic layer was dried over anhyd.MgSO4, solvents were concentrated in vacuo and the crude was purified by column chromatography to obtain 0.4g of the pure product.1H NMR 500 MHz CDCl3: 7.57, s, IH, 7.2, d, J=8.7, IH, 7.12, d, J=8.7, IH, 4.04, q, J=7.2, 2H, 2.73-2.64, m, 4H, 1.98-1.90, m, 2H, 1.88-1.81, m, 2H, 1.30, t, J=7.3, 3H.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-Bromo-2,3,4,9-tetrahydro-1H-carbazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; IMMUSOL INCORPORATED; WO2008/21745; (2008); A2;,
Bromide – Wikipedia,
bromide – Wiktionary