In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3344-70-5 as follows. Recommanded Product: 3344-70-5
General procedure: A dibromoalkane (1 equiv.) and sodium azide (3 equiv.) were dissolved in 4 : 1 DMF/H2O (15 mL). The mixture was irradiated in a CEM microwave reactor at 125oC (200 W, 200 psi) for 3 h. The reaction mixture was then cooled to room temperature, and 2-ethynylpyridine (2 equiv.), sodium ascorbate (0.5 equiv.), and CuSO4*5H2O (0.4 equiv.) were added to the reaction mixture. The mixture was stirred at room temperature for 12 h. The suspension was partitioned between aqueous 0.1M NH4OH/ethylenediaminetetraacetic acid (EDTA) (100 mL) and CH2Cl2 (100 mL), and the layers were separated. The organic phase was washed with water (100 mL) and brine (100 mL), dried over MgSO4, and the solvent was removed under reduced pressure to provide the ligands as off-white solids.
According to the analysis of related databases, 3344-70-5, the application of this compound in the production field has become more and more popular.
Reference:
Article; Kumar, Sreedhar V.; Lo, Warrick K. C.; Brooks, Heather J. L.; Hanton, Lyall R.; Crowley, James D.; Australian Journal of Chemistry; vol. 69; 5; (2016); p. 489 – 498;,
Bromide – Wikipedia,
bromide – Wiktionary