Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 49764-63-8, name is 4,5-Dibromobenzene-1,2-diamine, A new synthetic method of this compound is introduced below., Safety of 4,5-Dibromobenzene-1,2-diamine
General procedure: To a 10 mL vial were added o-diaminobenzene 2 (0.2 mmol, 1.0 equiv), DIPEA(0.24 mmol, 1.2 equiv), and toluene (2 mL), followed by the slow addition of a solution of-acetoxy allenoate 1 (0.24 mmol,1.2 equiv) in toluene (2 mL). The solution was stirred for 12 h atroom temperature. The reaction mixture was concentrated under reduced pressure, and the residuewas purified by silica gel column chromatography using petroleum ether and ethyl acetate (30:1 to15:1 v/v) as the eluent to give the corresponding annulations product 3.
The synthetic route of 49764-63-8 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Wang, Yi-Fan; He, Cheng-Yu; Hou, Longlei; Tian, Ping; Lin, Guo-Qiang; Tong, Xiaofeng; Synlett; vol. 29; 9; (2018); p. 1176 – 1180;,
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bromide – Wiktionary