Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5279-32-3, name is 5,6-Dibromobenzo[d][1,3]dioxole, A new synthetic method of this compound is introduced below., Quality Control of 5,6-Dibromobenzo[d][1,3]dioxole
Preparation of 5-(6-bromobenzo[d][1,3]dioxol-5-yl)pyrazin-2-amine (15).; Palladium tetrakis-triphenylphosphine (31 mg, 30 mumol) was added to a degassed solution of dibromide 10 (150 mg, 54 mumol) and boronate 14 (130 mg, 59 mumol) in dioxane:acetonitrile:water (9:9:2, 2.7 mL) and potassium carbonate (171 mg, 800 mumol). The resulting mixture was heated under argon at 90 C. with stirring for 2 h. The mixture was then cooled, diluted with dichloromethane (10 mL), dried with sodium sulfate and concentrated under reduced pressure. Flash chromatography (ISCO system, silica, 0-50% ethyl acetate in hexane) provided 15 (19.6 mg, 12%) as a solid: LRESIMS m/z 294.1 [M+H]+, calcd. for C11H9Br1N3O2 294.0.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; CalciMedica, Inc.; US2011/263612; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary