Application of 73918-56-6, These common heterocyclic compound, 73918-56-6, name is 2-(4-Bromophenyl)ethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a solution of compound 31 (99 mg, 0.30 mmol) in anhydrous DMF (5.0 mL) were added EDC (75 mg, 0.39 mmol) and HOBt (45 mg, 0.33 mmol) and then stirred under ice water bath for 5 min, then the selected amine (0.36 mmol) were employed to the reaction mixture for another 15 min at 0 C and stirred at room temperature for 3 h. The mixture was extracted with ethyl acetate, washed with water and brine, and then dried over anhydrous Na2SO4. The crude product was purified by column chromatography (SiO2, petroether/ethyl acetate) to afford target compounds 32-44.
Statistics shows that 2-(4-Bromophenyl)ethanamine is playing an increasingly important role. we look forward to future research findings about 73918-56-6.
Reference:
Article; Wu, Jing; Yu, Linxi; Yang, Feifei; Li, Jingjie; Wang, Peng; Zhou, Wenbo; Qin, Liwen; Li, Yunqi; Luo, Jian; Yi, Zhengfang; Liu, Mingyao; Chen, Yihua; European Journal of Medicinal Chemistry; vol. 80; (2014); p. 340 – 351;,
Bromide – Wikipedia,
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