In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 50548-45-3 as follows. Application In Synthesis of 1-Bromodibenzo[b,d]furan
180 g (728 mmol) of 1-bromodibenzofuran are dissolved in 1500 ml of dry THF and cooled to -78°C. 305 ml (764 mmol I 2.5 M in hexane) of n-butyllithium are added over the course of about 5 mm. at this temperature, and the mixture is subsequently stirred at -78°C for a further 2.5 h. 151 g (1456 mmol) of trimethyl borate are added as rapidly as possible at this temperature, and the reaction is slowly allowed to come to room temperature(about 18 h). The reaction solution is washed with water, and the solid which has precipitated out and the organic phase are dried azeotropically with toluene. The crude product is washed by stirring with toluene/methylene chloride at about 40°C and filtered off with suction. Yield: 146 g (690 mmol),95percent of theory.
According to the analysis of related databases, 50548-45-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK PATENT GMBH; PARHAM, Amir Hossain; JATSCH, Anja; EBERLE, Thomas; GROSSMANN, Tobias; KROEBER, Jonas Valentin; DOBELMANN-MARA, Lars; (100 pag.)WO2016/198144; (2016); A1;,
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bromide – Wiktionary