Adding a certain compound to certain chemical reactions, such as: 55289-36-6, name is 3-Bromo-2-methylaniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 55289-36-6, Recommanded Product: 55289-36-6
68A. 3-bromo-2-methylphenol To a solution of 3-bromo-2-methylaniline (6 g, 32.2 mmol) in sulfuric acid (38.7 mL, 38.7 mmol) at 0 C. was added slowly of a solution of sodium nitrite (2.67 g, 38.7 mmol). After stirring at 0 C. for 15 min, sulfuric acid (13.75 mL, 258 mmol) was added and the solution was heated at 100 C. for 1 h. The mixture was diluted with water, extracted with Et2O, dried and concentrated. Purification via silica gel chromatography gave 68A (light brown solid, 4.92 g, 82% yield).
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Reference:
Patent; Bristol-Myers Squibb Company; US2011/82165; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary