Adding a certain compound to certain chemical reactions, such as: 399-94-0, name is 1-Bromo-2,5-difluorobenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 399-94-0, Formula: C6H3BrF2
2-Bromo-3,6-difluorobenzaldehyde (C2.1) (0506) To a solution of 2-bromo-1,4-difluorobenzene (16 g, 83 mol) in 200 mL THF under N2 atmosphere at -78 C. was added LDA (54 mL, 108 mmol) dropwise. After stirring at -78 C. for 45 min, DMF (18.2 g, 249 mmol) was added. The mixture was stirred for another 2 h at -78 C. The reaction mixture was warmed up to 0 C., added 200 mL and sat. NH4Cl was added. The resulting mixture was extracted with EtOAc (200 mL×2). The combined organic layer was washed with brine (400 mL×1), dried over anhydrous Na2SO4, filtered and concentrated under vacuum to give crude product. The crude product was purified by column chromatography (silica, EtOAc/PE=1/30) to give the title compound (11 g, 60%) as a yellow solid. 1H NMR (500 MHz, CDCl3) delta ppm 7.57-7.34 (m, 2H), 10.20 (dd, 1H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2,5-difluorobenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Novartis AG; CHAN, Ho Man; GU, Xiang-Ju Justin; HUANG, Ying; LI, Ling; MI, Yuan; QI, Wei; SENDZIK, Martin; SUN, Yongfeng; WANG, Long; YU, Zhengtian; ZHANG, Hailong; ZHANG, Ji Yue (Jeff); ZHANG, Man; ZHANG, Qiong; ZHAO, Kehao; (134 pag.)US2016/176882; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary