Electric Literature of 2550-36-9, These common heterocyclic compound, 2550-36-9, name is (Bromomethyl)cyclohexane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A suspension of compound 33 (496 mg, 2.88 mmol), solid potassium hydroxide (182 mg, 3.24 mmol) and tetrabutyl ammonium bisulfate (11 mg, 0.29 mmol) in toluene (4 mL) was heated to 50 C and the reaction was conducted for 2 h with vigorous stirring. To the above reaction mixture bromomethyl cyclohexane (639 mg, 3.61 mmol) was added dropwise and the reaction mixture was heated to 80 C. After 2 h, the reaction was cooled to rt, diluted with ethyl acetate, washed with water, brine and dried over anhydrous Na2SO4. The organic layer was concentrated to yield the product 34 as a yellow oil which is a mixture of rotamers (720 mg, 2.68 mmol, 93%); 1H NMR (CDCl3) delta 0.84-1.07 (m, 2H), 1.08-1.32 (m, 4H), 1.44 and 1.50 (s, 9H), 1.57-1.77 (m, 5H), 1.80 and 1.86 (s, 3H), 2.03 and 2.06 (s, 3H), 3.31 (d, J = 8.00 Hz, 2H).
Statistics shows that (Bromomethyl)cyclohexane is playing an increasingly important role. we look forward to future research findings about 2550-36-9.
Reference:
Article; Purohit, Meena K.; Chakka, Sai Kumar; Scovell, Iain; Neschadim, Anton; Bello, Angelica M.; Salum, Norue; Katsman, Yulia; Bareau, Madeleine C.; Branch, Donald R.; Kotra, Lakshmi P.; Bioorganic and Medicinal Chemistry; vol. 22; 9; (2014); p. 2739 – 2752;,
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