Related Products of 454-79-5, A common heterocyclic compound, 454-79-5, name is 2-Bromo-5-(trifluoromethyl)aniline, molecular formula is C7H5BrF3N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a air atmosphere, a 10 ml flask was charged with 1.0 mmol of 5-methyl-2-hydroxybenzylalcohol, 1.4 mmol of 5-trifluoromethyl-2-bromoaniline,0.02 mmol p-cymene ruthenium dichloride dimer, 0.06 mmol copper bromide,0.07 mmol of 2,2′-bis (diphenylphosphino) -1,1′-binaphthyl,4.0 mmol of potassium hydroxide, and 5 ml of dioxane,The shelves were then heated in an oil bath with a magnetic stirrer to 110 C for 30 hours.The oil bath was removed, 3 ml of water was added to the reaction mixture and the mixture was extracted three times with 5 ml of ethyl acetate. The organic phases were combined and dried over anhydrous magnesium sulfate for 30 minutes. The filtrate was concentrated on a rotary evaporator. The concentrated solid was extracted with methylene chloride Recrystallization gave pure product 12 in 87% yield.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Luoyang Normal College; Xu Chen; Li Hongmei; Wang Zhiqiang; Lou Xinhua; Fu Weijun; (11 pag.)CN105949143; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary