Synthetic Route of 937046-98-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 937046-98-5, name is 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A mixture of 7-bromopyrrolo[2,1-f][1,2,4]triazin- 4-amine (250 mg, 1.174 mmol), (S)-1-tert-butyl 2-methyl 4-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)-1H-pyrrole-1,2(2H,5H)-dicarboxylate (912 mg, 2.58 mmol) and potassium phosphate tribasic (2 M in water) (1760 mul, 3.52 mmol) in DMF (6593 mul) was sparged with nitrogen for 5 min. PdCl2(dppf)-CH2Cl2 adduct (96 mg, 0.117 mmol) was added to the reaction mixture which was sparged with nitrogen for an additional 5 min. The mixture was brought to 100 C and stirred for 30 min. The reaction mixture was then diluted with EtOAc, washed with water, brine, dried over MgSO4, filtered and concentrated in vacuo. Purification by flash chromatography (Silica, 40g, 40 – 70% EtOAc/Hexanes) gave (S)-1-tert-butyl 2-methyl 4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7- yl)-1H-pyrrole-1,2(2H,5H)-dicarboxylate (165 mg, 0.459 mmol, 39.1 % yield). (0757) MS ESI (m/z) 360.1 (M+H)
The synthetic route of 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WATTERSON, Scott Hunter; ANDAPPAN MURUGAIAH SUBBAIAH, Murugaiah; DZIERBA, Carolyn Diane; GONG, Hua; GUERNON, Jason M.; GUO, Junqing; HART, Amy C.; LUO, Guanglin; MACOR, John E.; PITTS, William J.; SHI, Jianliang; VENABLES, Brian Lee; WEIGELT, Carolyn A.; WU, Yong-Jin; ZHENG, Zhizhen Barbara; SIT, Sing-Yuen; CHEN, Jie; (810 pag.)WO2019/147782; (2019); A1;,
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