Reference of 13633-25-5, A common heterocyclic compound, 13633-25-5, name is 1-Bromo-4-phenylbutane, molecular formula is C10H13Br, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
3) 0.24 g (10 mmol) of sodium hydride and 15 ml of N, N-dimethylformamide were added to a 50 ml round bottom flask at room temperatureStir for 10 minutes,Then, 2.5 g (10 mmol) of compound 2 and 10 mmol of 1-bromo-4-phenylbutane were added and subjected to thin layer chromatography to the end of the reaction. The reaction solution was then poured into 500 ml of ice water, extracted three times with 100 ml of ethyl acetate,The organic phase was combined and the solvent was evaporated to dryness. The resulting residue was purified by silica gel column chromatography (V dichloromethane: V methanol = 100: 1) to give Compound 3 (3.1 g, yield 82%).
The synthetic route of 13633-25-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangxi Normal University; Chen Zhenfeng; Liang Hong; Liu Yancheng; Lu Xing; Li Liangping; (13 pag.)CN106478690; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary