Adding a certain compound to certain chemical reactions, such as: 314084-61-2, name is 2-Bromo-1,3-diethyl-5-methylbenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 314084-61-2, name: 2-Bromo-1,3-diethyl-5-methylbenzene
Under a nitrogen atmosphere and at normal pressure, 14 g of malonic acid dinitrile dissolved in 7 ml of 1-methyl-2-pyrrolidone are added dropwise in the course of 30 minutes, at from 20 to 25C, to a mechanically stirred mixture of 64 g of sodium carbonate in 200 mi of 1-methyl-2-pyrrolidone. The reaction mixture is heated to 100C and 45.5 g of 2-bromo- 1, 3-diethyl-5-methylbenzene are added, after which the mixture is heated to 120C. At that temperature, a mixture of 0.26 g of TRIPHENYLPHOSPHINE, 0.21 g of a commercially available palladium (LI) chloride solution in concentrated hydrochloric acid (20% Pd content corresponding to 0.071 g of PALLADIUM (II) CHLORIDE in 0.142 g of concentrated hydrochloric acid) and 19.5 g of 1-methyl-2-pyrrolidone is added. The reaction mixture is stirred for from 2 to 3 hours at from 125 to 140C. A gas chromatogram of a sample (1 ml of reaction mixture partitioned between 2 ML of 1 N hydrochloric acid and 2 ml of tert-butyl methyl ether) shows that the product (2-(2, 6-DIETHYL-4-METHYLPHENYL) MALONIC acid dinitrile) has not formed.
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Reference:
Patent; SYNGENTA PARTICIPATIONS AG; WO2004/50607; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary