Adding a certain compound to certain chemical reactions, such as: 502496-36-8, name is 3-Bromo-5-fluoro-2-methylaniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 502496-36-8, Safety of 3-Bromo-5-fluoro-2-methylaniline
3-Bromo-5-fluoro-2-methylaniline (515 mg, 2.53 mmol) was dissolved in pyridine (20 ml). Then Intermediate 33 (547 mg, 2.53 mmol) and DMAP (3.09 mg, 0.025 mmol) were added and the resulting mixture was stirred at r.t. for 2 hrs. The solvents were removed in vacuo and the residue was taken up with EtOAc and H20. The organic layer was washed with sat. NaHC03 solution and brine, and then dried over Na2S04. The solvents were removed in vacuo and the resulting residue was recrystallized with MeOH to afford Intermediate 34 as colorless solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Bromo-5-fluoro-2-methylaniline, and friends who are interested can also refer to it.
Reference:
Patent; NOVARTIS AG; HENG, Richard; HOEGENAUER, Elizabeth, Kate; KOCH, Guido; PULZ, Robert, Alexander; VULPETTI, Anna; WAELCHLI, Rudolf; WO2013/8095; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary