These common heterocyclic compound, 955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C18H11BrO
250 ml of four-mouth bottle, in an atmosphere of nitrogen, adding 16.2 g 4 – (4 – bromo – phenyl) dibenzofuran (0.05 muM) and 1.44 gMg powder (0.06 muM), 60 ml tetrahydrofuran, heating reflux for 4 hours, the reaction is complete, generating format reagent; 11. 1g10, 10 – dimethyl anthrone (0.05 muM) dissolved in 50 ml in tetrahydrofuran, dropping the above-mentioned form reagent, 60 °C reaction 24 hours, generating a large amount of white precipitate, finally adding saturated NHCl4 The format salt into alcohol; after the reaction, diethyl ether extraction, drying and steaming and, petroleum ether: methylene chloride mixed solvent (3:2) silica gel column purification, to obtain slightly yellow solid tertiary alcohol (yield is 85percent);
The synthetic route of 4-(4-Bromophenyl)dibenzo[b,d]furan has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CECEP Wanrun Co., Ltd.; Zhang Zhaochao; Wang Lichun; Li Chong; (29 pag.)CN107056737; (2017); A;,
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