Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5433-01-2, name is 1-Bromo-3-isopropylbenzene, A new synthetic method of this compound is introduced below., SDS of cas: 5433-01-2
1-Bromo-3-isopropylbenzene 13 (1.5 g, 7.5 mmol, 1.0 eq.), acrolein-diethylacetal (3.57g, 23.43 mmol, 3.1 eq.), Bu4NOAc (5.0 g, 16.6 mmol, 2.2 eq.), potassium carbonate (1.56 g, 11.3 mmol, 1.5 eq.), potassium chloride (0.75 g, 7.6 mmol, 1.01 eq.) and palladium(II) acetate (50 mg, 0.22 mmol, 0.029 eq.) were suspended in DMF (32 mL) and heated for 24 h at 90C. The reaction mixture was cooled to room temperature, diluted with water (25 mL) and acidified with HCl 2M. After extraction with methyl-tert-butyl ether, the organic phase was washed with water and brine, dried over Na2SO4, filtered and concentrated. The residue was purified by chromatography on silica gel (hexane/EtOAc 19/1) to give 14 (928 mg, 71% yield).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Goncalves-Contal, Sylvie; Gremaud, Ludovic; Palais, Laetitia; Babel, Lucille; Alexakis, Alexandre; Synthesis; vol. 48; 19; (2016); p. 3301 – 3308;,
Bromide – Wikipedia,
bromide – Wiktionary