Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 399-94-0, name is 1-Bromo-2,5-difluorobenzene, A new synthetic method of this compound is introduced below., Safety of 1-Bromo-2,5-difluorobenzene
THF (25 mL) was added to Magnesium metal (2.55g, 105 mmol), and then 2-bromo-1,4-difluorobenzene (19.70g, 100mmol) was addedslowly to prepare a Grignard reagent. To separately prepared THF (10mL)solution of diethyl oxalate (15.34g, 105mmol), Grignard reagent preparedearlier was added dropwise at -40 below. After completion of the addition, it was stirred for 1 hour at thereaction temperature of 0 . saturated aqueous solution of ammonium chlorideand water (200 mL) were added to the reaction solution, and extracted with ethyl acetate (200mL ×2). The organic layer was dried over magnesium sulfate, filtered, and thesolvent was evaporatedunder reduced pressure, and by distillation under reducedpressure, colorless liquid of 2- (2,5-difluorophenyl) -2- oxo-ethyl acetate(14.82g, yield: 62%)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SAGAMI CHEMICAL RESEARCH INSTITUTE; KAKEN PHARMACEUTICAL COMPANY LIMITED; KOBAYASHI, OSAMU; TAKATSUNA, REIKO; NIIKURA, NAOKO; MATSUKAWA, TOMOKO; NAKAMURA, SHINJI; HIRAI, KENJI; KOCHI, SHINICHIRO; KAWANISHI, NAOKI; YAMADA, OSAMU; (75 pag.)JP2016/56157; (2016); A;,
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