Application of 1435-52-5, These common heterocyclic compound, 1435-52-5, name is 1,4-Dibromo-2-fluorobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
150ml three-necked flask, Add 0.01 mol of 2,5-dibromofluorobenzene, 0.012 mol of M2 0.02mol sodium carbonate and 10ml ethylene glycol dimethyl ether, protected by nitrogen Heat to 190 ° C and stir the reaction for 48 hours. Then cooled to room temperature and poured into a beaker. Add 50 ml of toluene and 50 ml of water and stir for 20 minutes. Filtered, the filtrate is steamed, Pass the silica gel column, Obtaining white intermediate 3a with a purity of 98.10percent, The yield was 77.5percent.
The synthetic route of 1435-52-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Ye Zhonghua; Zhang Zhaochao; Li Chong; Zhang Xiaoqing; (57 pag.)CN109575057; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary