These common heterocyclic compound, 21524-34-5, name is 2-Bromo-1,3,5-triisopropylbenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 21524-34-5
To a stirred tetrahydrofuran solution of bromide S12 (3.0 mmol) at -78 C was slowly added dropwise a solution of n-butyllithium (2.4M, 1.5 mL).After stirring for 30 minutes, phosphorus trichloride was added, and then the reaction mixture was warmed to room temperature and stirred for 12 hours.After the complete conversion (monitored by TLC), the prepared CuCl·LiCl complex and zinc zinc lithium benzoate complex were added to the reaction solution.The reaction was continued for 12 hours and quenched by adding water.The organic layer was separated, dried, filtered and concentrated in vacuo.The residue thus obtained was purified by silica gel column chromatography (petroleum ether: ethyl acetate ratio: 20: 1) to obtain S13 (72% yield).
The synthetic route of 2-Bromo-1,3,5-triisopropylbenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; South University of Science and Technology of China; Liu Xinyuan; Ma Canliang; Dong Xiaoyang; (27 pag.)CN110590841; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary