Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 33070-32-5, name is 5-Bromo-2,2-difluorobenzodioxole, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C7H3BrF2O2
A solution of 5-bromo-2,2-difluoro-1 ,3-benzodioxole (2.65 mmol), 4-(4,4,5,5- tetramethyl-1 ,3,2-dioxaborolan-2-yl)aniline (3.97 mmol), tetrakis(triphenylphosphine)palladium(0) (0.08 mmol), and cesium carbonate (7.94 mmol) in Lambda/,Lambda/-dimethylformamide (8.0 ml.) and water (2.0 ml_) was heated at 100 0C for 18 h. The reaction mixture was cooled, poured into brine (60 ml_), and extracted with ethyl acetate (3 x 50 ml_). The combined organic layers were dried over magnesium sulfate and decolorizing charcoal, filtered through Celite, and concentrated in vacuo. Purification of the residue by Gilson reverse phase HPLC and neutralization of the collected fractions afforded the title product as a white solid (50%). ESMS [M+H]+: 250.2.
According to the analysis of related databases, 33070-32-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; CYTOKINETICS; WO2006/20358; (2006); A2;,
Bromide – Wikipedia,
bromide – Wiktionary