Synthetic Route of 21120-91-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 21120-91-2, name is 7-Bromobicyclo[4.2.0]octa-1,3,5-triene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
7-bromobicyclo[4.2.0]octa- 1 ,3,5-triene (10.0 g,54.6 mmol) and ethylene glycol (100 mE) were added to a250 mE round-bottom flask. The biphasic mixture wascooled to 0 C. followed by the slow addition of solid silver(I) tetrafluoroborate (11.7 g, 60.1 mmol) to maintain a temperature of about 30 C. After addition, the reaction mixture was stirred at 50 C. for 3 hrs. Once cooled down to room temperature, 200 ml water and 400 ml ether were added. The resulting mixture was filtered through celite. The organic layer was washed three times with each 300 ml water and then dried over Na2504 and concentrated to give an oil. The oil was purified by column chromatography on silica gel using 5% ethyl acetate in hexanes (4.66 g). The product had the following characteristics: ?H-NMR (400 MHz, CDC13): oe 7.36-7.27 (m, 1H), 7.27-7.20 (m, 2H), 7.15 (dp, J=7.2, 1.0 Hz, 1H), 5.20-5.03 (m, 1H), 3.90-3.61 (m, 4H), 3.56-3.39 (m, 1H), 3.21- (m, 1H), 2.23-1.98 (br s, 1H). ?3C-NMR (101 MHz, CDC13): oe 145.64, 142.42, 129.49, 127.10, 123.54, 122.70, 76.96, 69.75, 61.91, 38.53
The synthetic route of 7-Bromobicyclo[4.2.0]octa-1,3,5-triene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Dow Global Technologies LLC; Grigg, Robert David; Spencer, Liam P.; Kramer, John W.; Liu, Chun; Mukhopadhyay, Sukrit; Devore, David D.; Feng, Shaoguang; Feng, Jichang; Zhu, Minrong; (27 pag.)US2018/212180; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary