Synthetic Route of 1422-54-4, These common heterocyclic compound, 1422-54-4, name is 2-Bromo-6-fluorotoluene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Active magnesium (10 mmol) was added in a RB containing dry THF (10 ml) and added a little iodine and stirred the reaction mixture and to this was added compound 1 (in 2 ml THF) slowly and stirred to generate the Grignard reagent. The reaction mixture was cooled to 0 C. and added compound 2 (in THF) drop wise and stirred the reaction mixture at rt for 2 h. After 2 h the reaction mixture was quenched with saturated NH4Cl solution and extracted with EtOAc. The organic layer washed with water, brine, dried over sodium sulphate and evaporated under reduced pressure to obtain compound 3.
Statistics shows that 2-Bromo-6-fluorotoluene is playing an increasingly important role. we look forward to future research findings about 1422-54-4.
Reference:
Patent; CELLIX BIO PRIVATE LIMITED; Kandula, Mahesh; US9175008; (2015); B1;,
Bromide – Wikipedia,
bromide – Wiktionary