Some tips on 39478-78-9

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Bromo-2-methylaniline, its application will become more common.

Application of 39478-78-9,Some common heterocyclic compound, 39478-78-9, name is 5-Bromo-2-methylaniline, molecular formula is C7H8BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1 Preparation of 3-amiotano-4′-chloro-4-methylbiotaphenylTeirakiotas(triotapnenylphosphiotane)palladiotaum (0) (3 7 g, 0 003 mol) and 4-chlorophenylboroniotac acid (20 2 g, 0 13mol) are added to a solution of 5-bromo-2-methylaniotaliotane (20 g, 0 1 mol) in 1 ,2- dimethoxyethane (200 ml) After stirring the reaction mixture for 15 minutes at 2O0C, a solution of 20% aqueous sodium carbonate (300ml) is added to the mixture, and the resulting mixture is heated at reflux for 24 hours. The reaction mixture is cooled to room temperature, diluted with water (600 ml) and extracted using ethyl acetate. The combined organic extracts are dried over anhydrous sodium sulfate, filtered and the filtrate evaporated in vacuo. The residue is further purified by column chromatography on silica gel, eluting with 7% ethyl acetate in hexane to give 3-amino-4′-chloro-4-methylbiphenyl (21.0 g).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Bromo-2-methylaniline, its application will become more common.

Reference:
Patent; SYNGENTA LIMITED; WO2008/145336; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary