Synthetic Route of 59907-12-9, A common heterocyclic compound, 59907-12-9, name is 1-Bromo-2-fluoro-3-methylbenzene, molecular formula is C7H6BrF, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1-Bromo-3-bromomethyl-2-fluorobenzene Obtained according to Example E but starting from 1-bromo -2-fluoro- 3-methylbenzene (prepared according to M. S. Newman and R. Kannan, J. Org. Chem., 1976, 41, 3356) and distilling the final product at 20 mm Hg. Yd.: 66% B.p.20 =95-105 C. 1 H N.M.R. (CDCl3): 4.4 (2H, s), 6.6 to 7.6 (3H, m).
The synthetic route of 59907-12-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Lipha, Lyonnaise Industrielle Pharmaceutique; US5489592; (1996); A;,
Bromide – Wikipedia,
bromide – Wiktionary