In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1422-54-4, name is 2-Bromo-6-fluorotoluene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 1422-54-4
1-Bromo-3-fluoro-2-methylbenzene (388mg, 2.05mmol), and (4-methoxyphenyl)methanol 5 (0.51 1 mL, 4mmol) were dissolved in DMF (5ml_) in a microwave vessel. Sodium hydride as a 60% dispersion in mineral oil (164mg, 4.0mmol) was added portionwise under a flow of nitrogen over 10min. The reaction vessel was then sealed and heated at 18O0C for 900s. The crude reaction mixture was poured onto 1 :1 wate?brine (6ml_) and DCM (1 OmL). The biphasic mixture was stirred at ambient temperature for 1 h and then the 10 organic and aqueous layers were separated. The combined organics were dried over Na2SO4 and concentrated in vacuo. The crude material was then purified by chromatography on silica gel. Elution with 5:95 ethyl acetate:heptane afforded 1-bromo-3- (4-methoxybenzyloxy)-2-methylbenzene (289mg, 0.9mmol, 46%).
The synthetic route of 1422-54-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; N.V. ORGANON; WO2007/63071; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary