Electric Literature of 7073-94-1, These common heterocyclic compound, 7073-94-1, name is 1-Bromo-2-isopropylbenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A sealed 10mL glass tube containing substrate 1a-1s (1.5mmol), trimethylsilylacetylene (1.5mmol), triethylamine (7.5mmol), Pd(PPh3)2Cl2 (5mol%), CuI (10mol%), and acetonitrile (1mL) was placed in the cavity of a microwave reactor and irradiated for 2-10min, at 120C and power 150W. After cooling to room temperature by an N2-flow, the tube was removed from the rotor. The reaction mixture was combined with dichloromethane (30mL) and water (30mL). The organic layer was separated and washed with water (2×30mL), dried over sodium sulfate, and concentrated. Purification by column chromatography, eluting with petroleum ether gave 1-aryl-2-(trimethylsilyl)acetylenes (2a-2s) as coloured oils or solids. All the products 2a-2s were characterized by 1H NMR and EI-MS. (See Supporting Information file for characterization data of 1H NMR and EI-MS spectrum.)
The synthetic route of 7073-94-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Lei, Yonghua; Hu, Tianhan; Wu, Xingsen; Wu, Yue; Xiang, Hua; Sun, Haopeng; You, Qidong; Zhang, Xiaojin; Tetrahedron Letters; vol. 57; 10; (2016); p. 1100 – 1103;,
Bromide – Wikipedia,
bromide – Wiktionary