Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 28342-75-8, name is 1,5-Dibromo-2,4-difluorobenzene, A new synthetic method of this compound is introduced below., Quality Control of 1,5-Dibromo-2,4-difluorobenzene
A cooled (-78 C) solution of diisopropylamine (2.25 mL, 16 mmol) in dry THF (10 mL) was treated with n-BuLi (10 mL, 16 mmol, 1.6 M) and then allowed to warm to room temperature. This LDA solution was added drop wise to a solution of l,5-dibromo-2,4- difluorobenzene (3.50 g, 13 mmol) in dry THF (20 mL) at -78 °C. The solution was stirred at -78 °C for 20 minutes, dry C02(g) was bubbled through it, it was warmed to room temperature and dil HCl (10 mL) was added, extracted to DCM, dried (MgS04) and evaporated. Yield (2.73 g, 67 percent) as a pale white solid. 1H NMR (CDC13): delta 8.35 (1H, t, J=9 Hz).
The synthetic route of 28342-75-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CAMBRIDGE DISPLAY TECHNOLOGY LIMITED; SUMITOMO CHEMICAL COMPANY LIMITED; STEUDEL, Annette; KOZHEVNIKOV, Valery; WO2014/9715; (2014); A1;,
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bromide – Wiktionary