Synthetic Route of 766-46-1, These common heterocyclic compound, 766-46-1, name is 2′-Bromophenylacetylene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In an appropriate amount of organic solvent DMSO,Adding 100 mmol of the compound of the above formula (I),170 mmol of the compound of the above formula (II),5 mmol two-component composite catalyst (a mixture of 1.5 mmol PdCl 2 (cod) and 3.5 mmol ferrocene), 18 mmol of the above ligand L1130 mmol of oxidant m-chloroperoxybenzoic acid and 25 mmol of acid promoter trifluoroacetic acid,After joining,The temperature was raised to 45 C and the reaction was stirred at this temperature for 6 hours.After the reaction is over,Cool naturally to room temperature,filter,The filtrate was washed thoroughly with deionized water and then with acetic acidEster extraction 2-3 times,Combine the organic phase,And dried over anhydrous magnesium sulfate,Concentrated under reduced pressure,The residue was separated by silica gel column chromatography.An equal volume ratio of a mixture of n-pentane and acetone is used as an elution solvent.Thereby obtaining a compound of the above formula (III),The yield was 96.7%.
The synthetic route of 766-46-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Yancheng Geruiyin Chemical Co., Ltd.; Ding Gang; (10 pag.)CN105130769; (2018); B;,
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