Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 766-81-4, name is 3-Bromophenylacetylene, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 766-81-4
General procedure: Step1: A mixture of Zn (3 mmol, 196.1 mg, activated by washing with dilute HCl) MeI(6 mmol, 851.6 mg) or EtI (6 mmol, 935.8 mg), phenylacetylene (2 mmol, 204.3mg) and NMP(0.5 mL) was stirred at room temperature until Zn disappeared (~ 2 h). Step 2 CH2Cl2(5 mL) and alpha-ketoneester (0.5 mmol) (oran aldehyde ) wereadded to the mixture of step 1 and the reaction was allowed to proceed at room temperature. After stirredfor ~12 h, the reaction was shown to be complete by TLC. A saturated ammonia chloride solution (10 mL)was added and the organic phase was separated.The water phase was extracted with CH2Cl2. The combined organic phase was washed withsaturated sodium chloride solution and dried with anhydrous sodiumsulfate. After concentration and column chromatograph on silica gel eluted with petroleumether/ethyl acetate (10:1), the product was obtained.
According to the analysis of related databases, 766-81-4, the application of this compound in the production field has become more and more popular.
Reference:
Article; Zhang, Wen; Cao, Yuan; Chen, Wei; Zhao, Gang; Pu, Lin; Tetrahedron Letters; vol. 56; 46; (2015); p. 6430 – 6432;,
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