Synthetic Route of 7745-91-7,Some common heterocyclic compound, 7745-91-7, name is 3-Bromo-4-methylaniline, molecular formula is C7H8BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Aniline derivative was added to a vessel containing HCl 37% (0.5ml) and the mixture was stirred in ice bath at 0-5C. Then, NFSPI 10 was added to the mixture and grinded at room temperature for the times shown in Table2 to produce the related diazonium salt. The phenolate compound was added slowly to the mixture to produce the desired azo dye at 0-5C. After completion of the reaction, ethyl acetate was added to the reaction mixture and stirred thoroughly. Then, poly ionic compound 9 was filtered off and the crude azo dye was isolated by evaporation of ethyl acetate. For more purification, crude product was recrystallized from ethanol/H2O. The products were characterized by their FT-IR, 1H-NMR and 13C-NMR spectra.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Bromo-4-methylaniline, its application will become more common.
Reference:
Article; Valizadeh, Hassan; Shomali, Ashkan; Ghorbani, Jalal; Noorshargh, Saeideh; Dyes and Pigments; vol. 117; (2015); p. 64 – 71;,
Bromide – Wikipedia,
bromide – Wiktionary