Application of 337915-79-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 337915-79-4 name is 5-Bromo-N1-methylbenzene-1,2-diamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
In a microwave vial, a mixture of 5-bromo-N1 -methylbenzene-1 ,2-diamine (0.20 g, 0.99 mmol), terephthalaldehyde (66 mg, 0.49 mmol) and sodium metabisulfite (0.22 g, 1 .19 mmol) in anhydrous N,N?-dimethylacetamide (5.00 ml.) was heated at 180 C for 30 min. The reaction mixture was cooled to room temperature and slowly poured into ice cold water (30 mL). The precipitated product was collected by filtration under vacuum to obtain the crude product. The product was recrystallized from hot methanol, filtered under vacuum and dried to obtain 1 , 4-bis (6-bromo-1 -methyl-1 H-benzo[d]imidazol-2-yl) benzene. 1 H NMR (400 MHz, DMSO-d6) d: 8.08 (s, 4H), 7.98 (s, 2H), 7.68 (d, J = 8.4 Hz, 2H), 7.41 (d, J = 8.4 Hz, 2H), 3.96 (s, 6H); MS (ESI + APCI): m/z = 497 [M + H]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Bromo-N1-methylbenzene-1,2-diamine, and friends who are interested can also refer to it.
Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; EXPANSION THERAPEUTICS, INC.; DISNEY, Matthew; BLIZZARD, Timothy, Allen; RZUCZEK, Suzanne; NDUNGU, John; VACCA, Joseph; JENNINGS, Andy; PUSHECHNIKOV, Alexei; (333 pag.)WO2019/99777; (2019); A2;,
Bromide – Wikipedia,
bromide – Wiktionary