Reference of 2635-13-4,Some common heterocyclic compound, 2635-13-4, name is 5-Bromobenzo[d][1,3]dioxole, molecular formula is C7H5BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Aryl bromine (0.5 mmol), phenylboronic acid (0.75 mmol) and K3PO4 (1mmol) was added in a 10mL reaction vial, which was closed with a rubber septum and evacuated and backfilled with nitrogen. Then 4 mL of 50% ethanol aqueous solution was added into the vial, 0.01mol% of PdNPs (according to 4-bromoanisole) water solution was injected into the vial, the reaction was carried out in at room temperature. The reaction process was monitored by TLC. The result product was extracted with ethyl acetate and purified by silica column chromatography.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Bromobenzo[d][1,3]dioxole, its application will become more common.
Reference:
Article; Ge, Jiyuan; Jiang, Jian; Yuan, Chenhuan; Zhang, Chaozhi; Liu, Minghua; Tetrahedron Letters; vol. 58; 12; (2017); p. 1142 – 1145;,
Bromide – Wikipedia,
bromide – Wiktionary