Extended knowledge of 5433-01-2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5433-01-2, its application will become more common.

Some common heterocyclic compound, 5433-01-2, name is 1-Bromo-3-isopropylbenzene, molecular formula is C9H11Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 5433-01-2

1 -Bromo-3-isopropylbenzene (200 g, 954 mmol, 1 eq) is dissolved in 1 I of 1-methyl-2-pyrro- lidone. Zinc cyanide (114 g, 954 mmol, 1 eq) and Pd(PPh3)4 (28.7 g, 24.8 mmol, 0.03 eq) are added under nitrogen. The reaction mixture is heated to 125C, stirred at this temperature for 150 min, then cooled to rt and filtered over Hyflo Super Gel, and the filtrate is diluted with H2O and EtOAc. The organic layer is washed with water, 1 N HCI solution and brine, dried -~ over sodium sulfate, filtered and concentrated. The residue is purified by column chromatography using DCM/hexane in a ratio of 1 to 3 to give the product. HPLC (Nucleosil C18HD, 4×70 mm, 3 mum, 20-100% MeCN (6 min), 100% MeCN (3 min)) retention time: 5.06 min.1H-NMR (400 MHz, CDCI3): 7.57 (s, 1H), 7.53-7.48 (m, 2H), 7.43 (t, 1H), 3.01-2.92 (m, 1H), 1.29 (d, 6H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5433-01-2, its application will become more common.

Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2007/77004; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary